Man dead, four injured in Canley Heights shooting believed to be linked to organised crime

A man has died and four others have been seriously injured following a shooting in Sydney's south-west, which is believed to be organised crime-related.

Two men, aged 28 and 32, presented with multiple wounds at Liverpool Hospital about 8:30pm on Tuesday, with police called to attend.

The 28-year-old, Alai Ahio, underwent treatment for a gunshot injury, but died a short time later.

Sources told the ABC Mr Ahio had links to Western Sydney drill rap group OneFour.

The other man remains in a stable condition with a neck injury.

Shortly after 8:40pm, another two men, aged 23 and 22, attended Fairfield Hospital in a serious condition.

The 23-year-old had a gunshot injury to his neck.

Both men were moved to different hospitals for further treatment.

A 19-year-old man who presented to Liverpool Hospital at 9:50pm in a stable condition was also treated for injuries.

CCTV vision from the scene shows flashes from inside the garage of the home, and later, a large police response in the aftermath.

A crime scene was established at a home in Canley Heights, where police believe all men were injured during a shooting on Tuesday night.

Detective Superintendent Craig Middleton said police were looking for two men who fled the home in a white SUV.

"I can confirm that police are looking for two males that entered the premises shortly before 8:20pm where a number of gunshots were heard from that premises," he said.

He said the five victims were known to each other, with one of the survivors in intensive care and the others awaiting further surgery.

'Brazen, violent attack'

Superintendent Middleton described the incident as a targeted attack, but the motive for the shooting was under investigation.

"We are aware of some organised crime links, although I can't confirm that at this stage," he said.

"This is a brazen, violent attack on five people inside their home, so it is of concern to us."

Taskforce Falcon was set up last year with hundreds of detectives to target gangland conflict after a deadly war erupted within the Alameddine crime family.

Superintendent Middleton said the task force was involved in the Canley Heights investigation.

"Hopefully we can identify these offenders and arrest them quickly and prevent this whole thing occurring again," he said.